Publikationen

Publications



Genetic Ablation of L-Type Ca2+ Channels Abolishes Depolarization-Induced Ca2+ Release in Arterial Smooth Muscle.


Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, Ureña J, López-Barneo J

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.


Lukowski R, Rybalkin SD, Loga F, Leiss V, Beavo JA, Hofmann F

Ido brings down the pressure in systemic inflammation.


Hofmann F

cGMP-dependent protein kinase Type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala.


Paul C, Stratil C, Hofmann F, Kleppisch T

IRAG determines NO- and ANP-mediated smooth muscle relaxation.


Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Höcherl K, Feil R, Feil S, Lukowski R, Wegener JW, Hofmann F, Schlossmann J

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.


Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL

Effects of cGMP-dependent protein kinase knockouts.


Hofmann F & Kleppisch T

Handb. Cell Signaling. 2009, 1515-1518

Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle.


Frei E, Huster M, Smital P, Schlossmann J, Hofmann F, Wegener JW

Combined Reporter Gene PET and Iron Oxide MRI for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart.


Higuchi T, Anton M, Dumler K, Seidl S, Pelisek J, Saraste A, Welling A, Hofmann F, Oostendorp RA, Gansbacher B, Nekolla SG, Bengel FM, Botnar RM, Schwaiger M

Polymorphisms determine beta-adrenoceptor conformation: implications for cardiovascular disease and therapy.


Ahles A, Engelhardt S

Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle.


Frei E, Hofmann F & Wegener JW

GPCR and G proteins: drug efficacy and activation in live cells.


Vilardaga JP, Buenemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ & Hoffmann C

cGMP-dependent protein kinase II and aldosterone secretion.


Spiessberger B, Bernhard D, Herrmann S, Feil S, Werner C, Luppa PB, Hofmann F

Analysis of receptor oligomerization by FRAP microscopy.


Dorsch S, Klotz K-N, Engelhardt S, Lohse MJ & Bünemann M

Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction.


Lewin G, Matus M, Basu A, Frebel K, Rohsbach SP, Safronenko A, Seidl MD, Stümpel F, Buchwalow I, König S, Engelhardt S, Lohse MJ, Schmitz W & Müller FU

cGMP Regulated Protein Kinases (cGK).


Hofmann F, Bernhard D, Lukowski R & Weinmeister P

Phosphodiesterases in the central nervous system.


Kleppisch T

cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour.


Kleppisch T & Feil R

Voltage-dependent calcium channels.


Welling A

BioTrend Rev. 2009, 4, 1-11

Signaling through cGMP-dependent protein kinase I in the amygdala is critical for auditory-cued fear memory and long-term potentiation.


Paul C, Schöberl F, Weinmeister P, Micale V, Wotjak CT, Hofmann F & Kleppisch T

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.


Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J & Engelhardt S

NO/cGMP-dependent modulation of synaptic transmission.


Feil R & Kleppisch T

Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: A role for ER stress?


Cook AR, Bardswell SC, Pretheshan S, Dighe K, Kanaganayagam GS, Jabr RI, Merkle S, Marber MS, Engelhardt S & Avkiran M

Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells.


Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L. Hofmann  &  Feil R

Unchanged ß-adrenergic stimulation of cardiac L-type calcium channels in Cav1.2 phosphorylation site S1928A mutant mice.


Lemke T, Welling A, Christel CJ, Blaich A, Bernhard D, Lenhardt P, Hofmann F & Moosmang S

Tamoxifen-inducible gene deletion in the cardiac conduction system.


Hoesl E, Stieber J, Herrmann S, Feil S, Tybl E, Hofmann F, Feil R & Ludwig A

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.


Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zernecke A, Weber C, Hofmann F & Feil R

Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells.


Lacinova L, Moosmang S, Langwieser N, Hofmann F & Kleppisch T

Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.


Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher HD, Hofmann F, Tegeder I, Ruth P & Geisslinger G

Phosphorylation of GSK-3b by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.


Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U-il & Kawaguchi H

Anemia and splenomegaly in cGKI-deficient mice.


Föller M, Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, Hofmann F, Schuler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber,SM, Lang & Feil R

Ultrastructural evidence for pre- and postsynaptic localization of Cav1.2 L-type Ca2+ channels in the rat hippocampus.


Tippens AL, Pare J-F, Langwieser N, Moosmang S, Milnewr TA, Smith Y & Lee A

Severe instestinal obstruction on induced smooth musle-specific ablation of the transcription factor SRF in adult mice.


Angstenberger M, Wegener JW, Pichler BJ, Judenhofer MS, Feil S, Alberti S, Feil R & Nordheim A

IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.


Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S & Schlossman J

Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola(Guttiferae).


Azebaze AGB, Dongmo AB, Meyer M, Ouahouo BMW, Valentin A, Nguemfo EL, Nkengfack AE & Vierling W

Ablation of connexin43 in smooth muscle cells of the mouse intestine: functional insights into physiology and morphology.


Döring B, Pfitzer G, Adam B, Liebregts T, Eckardt D, Holtmann G, Hofmann F, Feil S, Feil R & Willecke K

Vasodilator effect of the extracts and some coumarins from the stem bark of Mammea africana (Guttiferae).


Dongmo AB, Azebaze AGB, Nguelefack TB, Ouahouo BM, Sontia B, Meyer M, Nkengfack AE, Kamanyi A & Vierling W

Vasodilator effect of the extracts and some coumarins from the stem bark of Mammea africana (Guttiferae).


Dongmo AB, Azebaze AGB, Nguelefack TB, Ouahouo BM, Sontia B, Meyer M, Nkengfack AE, Kamanyi A & Vierling W

Alternative signaling: cardiomyocyte beta1-adrenergic receptors signal through EGFRs.


Engelhardt S

G proteins: more than transducers of receptor-generated signals?


Engelhardt S & Rochais F

Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca 2+ sparks in murine arterial smooth muscle cells.


Essin K, Welling A, Hofmann F, Luft FC, Gollasch M & Moosmang, S

A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart.


Frost RJ & Engelhardt S

Ca2+ channel currents and contraction in Ca-V beta (3)- deficient ileum smooth muscle from mouse.


Held B, Tsvilovskyy V, Meissner M, Kaestner L, Ludwig A, Moosmang S, Lipp P, Freichel M & Flockerzi V

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.


Herrmann S, Stieber J, Stöckl G, Hofmann F & Ludwig A

A role for caspase-1 in heart failure.


Merkle S, Frantz S, Schön MP, Bauersachs J, Buitrago M, Frost RJ, Schmitteckert EM, Lohse MJ & Engelhardt S

Analysis of calcium channels by conditional mutagenesis.


Moosmang S, Kleppisch T, Wegener J, Welling A & Hofmann F

Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1 adrenergic receptor.


Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE

Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol.


Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ & Engelhardt S

Activation of AP-1 Contributes to the beta-Adrenoceptor-Mediated Myocardial Induction of Interleukin-6.


Rohrbach S, Engelhardt S, Lohse MJ, Werdan K, Holtz J & Muller-Werdan U

Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+ - activated K+ channel.


Sausbier M, Zhou XB, Beier C, Sausbier U, Wolpers D, Maget S, Martin C, Dietrich A, Ressmeyer AR, Renz H, Schlossmann J, Hofmann F, Neuhuber W, Gudermann T, Uhlig S, Korth M & Ruth P

The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.


Schmidt H, Stonkute A, Jüttner, R, Schäffer S, Buttgereit J, Feil R, Hofmann F & Rathjen FG

Interstitial remodeling in beta1-adrenergic receptor transgenic mice.


Seeland U, Selejan S, Engelhardt S, Müller P, Lohse MJ & Böhm M

MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure.


Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G & Bauersachs J

Circulation 2007, 116, 258-267, 2. Erratum in: Circulation 116

Rescue of cGMP kinase I knockout mice by smooth muscle-specific expression of either isozyme.


Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Valtcheva N, Feil S, Schlossmann J, Hofmann F & Feil R

cGMP signals mainly through cAMP kinase in permeabilized murine aorta.


Wörner R, Lukowski R, Hofmann F & Wegener JW

Goldstein PA. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons.


Ying SW, Jia F, Abbas SY, Hofmann F, Ludwig A & Goldstein PA

Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).


Azebaze AGB, Dongmo AB, Meyer, M, Ouahouo BMW, Valentin A, Nguemfo EL, Nkengfack AE & Vierling W

Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated-caspase-3-independent cell death.


Boesten LS, Zadelaar SM, de Clercq S, Francoz S, van Nieuwkoop A, Biessen EAL, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJM & Marine JC

A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-I a does not regulate NPR-A.


Bryan PM, Smirnov D, Smolenski A, Feil S, Feil R, Hofmann F, Lohmann S & Potter LR

Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition.


Döring B, Shynlova O, Tsui P, Eckardt D, Janssen-Bienhold U, Hofmann F, Feil S, Feil R, Lye SJ & Willecke K

cGMP-dependent protein kinase Type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes.


Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM & Wollert KC

The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes.


Gomes B, Savignac M, Cabral MD, Paulet P, Moreau M, Leclerc C, Feil R, Hofmann F, Guéry JC, Dietrich G & Pelletier L

Gs activation is time-limiting in initiating receptor-mediated signaling.


Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ & Bünemann M

Function of cGMP-dependent protein kinases as revealed by gene deletion.


Hofmann F, Feil R, Kleppisch T & Schlossmann J

Gating of the expressed T-type Cav3.1 calcium channels is modulated by Ca2+.


Lacinova L, Kurejova M, Klugbauer N & Hofmann F

Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel.


Lee TS, Karl R, Moosmang S, Lenhardt P, Klugbauer N, Hofmann F, Kleppisch T & Welling A

Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.


Moosmang S, Haider N, Brüderl B, Welling A & Hofmann F

Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels.


Meuth SG, Kanyshkova T, Meuth P, Landgraf P, Munsch T, Ludwig A, Hofmann F, Pape HC & Budde, T

Spasmolytic effects of extracts from Kalanchoe crenataandrews (Crassulaceae) leaves.


Nguelefack TB, Sontia B, Dongmo AB, Dimo T, Kamanyi A & Vierling W

Pharmacologyonline 2006, 1, 30 – 39

Bradycardic and proarrhythmic properties of sinus node inhibitors.


Stieber J, Wieland K, Stöckl G, Ludwig A & Hofmann F

Besonderheiten der Arnzeimittelanwendung im Alter.


Vierling W

In Medizin des Alterns und des alten Menschen 2006, Hrsg. Werner Hansen, Schattauer Verlag Stuttgart, 94 – 115

Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.


Vignali S, Leiss V, Karl R, Hofmann F & Welling A

Control of intestinal motility by the Cav1.2 L-type calcium channel in mice.


Wegener J, Schulla V, Koller A, Klugbauer N, Feil R & Hofmann F

Activation of CFTR by ASBT-mediated bile salt absorption. 


Bijvelds MJ, Jorna H, Verkade HJ, Bot AG, Hofmann F, Agellon LB, Sinaasappel M & de Jonge JR

The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. 


Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ & Engelhardt S

Impaired neocortical organization in mice lacking cGMP-dependent protein kinase I.


Demyanenko GP, Halberstadt AI, Pryzwansky KB, Werner C, Hofmann F & Maness PF

Beta-adrenergic receptors in heart failure. 


Engelhardt S

A heretical view on the role of NO and cGMP in vascular proliferative diseases. 


Feil R, Feil S & Hofmann F

Function of cGMP-dependent protein kinases in the nervous system.


Feil R, Hofmann F & Kleppisch T

Distribution of cGMP-dependent protein kinase Type I and its isoforms in the mouse brain and retina. 


Feil S, Zimmermann P, Knorn A, Brummer S, Schlossmann J, Hofmann F & Feil R

Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling.


Frambach T, Müller T, Freund S, Engelhardt S, Sütterlin M, Lohse MJ & Dietl J

Schrittmacherkanäle: Wächter an Hirn und Herz. 


Herrmann S, Stieber J, Ludwig A & Hofmann F

Jahrbuch 2004 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) 2005, 50, 421 – 428 

The biology of cyclic GMP-dependent protein kinases.


Hofmann F

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.


Hofmann F, Biel M & Kaupp B

Ca2+ -and voltage-dependent inactivation of the expressed L-type Cav1.2 calcium channel. 


Lacinova L & Hofmann F

Cre/loxP-vermittelte konditionale Mutagenese des cGMP-Signalwegs in der Maus. 


Lukowski R, Weber S, Weinmeister P, Feil S & Feil R

Biospektrum 2005, 3, 287 – 290

Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.


Michalakis S, Geiger H, Haverkamp S, Hofmann F, Gerstner A & Biel M

Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. 


Moosmang S, Haider N, Klugbauer N, Adelsberger H, Langwieser N, Müller J, Stiess M, Marais E, Schulla V, Lacinova L, Goebbels S, Nave KA, Storm DR, Hofmann F & Kleppisch T

Mouse models to study L-type calcium channel function.


Moosmang S, Lenhardt P, Haider N, Hofmann F & Wegener JW

Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis.


Nikolaev VO, Gambaryan S, Engelhardt S, Walter U & Lohse MJ

Insights into cGMP signalling derived from cGMP kinase knockout mice.


Schlossmann J, Feil R & Hofmann F

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.


Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Adullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M & Ruth P

cGMP-dependent protein kinases in drug disvovery.


Schlossmann J & Hofmann F

Bedeutung des Schrittmacherkanals HCN4 im embryonalen Herzen der Maus.


Stieber J

Biospektrum 2005, 2, 213 – 214

Functional expression of the human HCN3 channel.


Stieber J, Stöckl G, Herrmann S, Hassfurth B & Hofmann F

Effects of polyphenols and magnesium on functions of heart and vascular smooth muscle: similarities and differences.


Vierling W, Sontia B, Müller B & Wagner H

In Biopolyphenol und Magnesium – Südsteirische Schätze, eds S. Porta and D. Gualtieri, 1st edition 2005, 104 – 116 (Edition B, Graz, Österreich)

25th Magnesium-Symposium of the Society of Magnesium Research, 8.-9. Okt. 2004 in München.


Vierling W

J. Trace Elem. Electrolytes Health Dis. 2005, 22, 160 – 168

Inhibition of L-type Cav1.2 Ca2+ -channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Gö6983).


Welling A, Hofmann F & Wegener JW

Neutrophil dysfunction in guanosine 3`,5`-cyclic monophosphate-dependent protein kinase I-deficient mice.


Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D, Schlossmann J, Schiemann M, Hofmann F & Pryzwansky KB

Cyclic Nucleotide-Regulated Cation Channels.


Biel M & Hofmann F

In Encyclopedia of Biological Chemistry, eds. Lennarz, W. u. Lane, M.D., Elsevier Science (USA) 2004, Volume 1, 512-515