News of the IPT
Ministry promotes development of Covid-19 drug: A spray against lung damage in Corona
rnatics, a start-up at the Technical University of Munich (TUM), has developed an RNA-based agent to prevent inflammatory lung damage. These occur particularly in severe corona processes. The German Federal Ministry of Education and Research (BMBF) is supporting further development of the drug with around 7 million euros. The rnatics team is focusing on a substance that blocks proinflammatory microRNA.
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Epigenetic mechanisms for parent-specific genetic activation decoded - Unmuting the genome
Hereditary diseases as well as cancers and cardiovascular diseases may be associated with a phenomenon known as genomic imprinting, in which only the maternally or paternally inherited gene is active. An international research team involving scientists at the Technical University of Munich (TUM), the Max Planck Institute for Molecular Genetics (MPIMG) in Berlin and Harvard University in Cambridge (USA) has now investigated the mechanisms responsible for the deactivation of the genes.
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A small RNA allows for therapeutic modulation of cardiac arrhythmias
Dena Esfandyari and colleagues discovered a crucial role of microRNA-365 (miR-365) in regulating human cardiac action potential. An abnormal cardiac action potential may lead to different types of life-threatening arrhythmias. This study suggests that miR-365 normalizes the pathologically altered action potential by modulating key cardiac repolarizing channels. These findings have been recently published in Nature Communications(link is external).
Otto-Hess scholarship for Sönke Michel
SFB Project Retreat 2021 in Alpbach
From November 11th to 13th about 80 scientists from SFB TRR 267 were meeting in Alpbach for the annual project retreat. The impressive scenery fo the Alpbachtal created an ideal atmosphere for scientific exchange and networking within a variety of project presentations, poster sessions as well as the supporting framework program.
Hans-Jürgen-Bretschneider-Abstract-Prize at the DGK Herztage 2021
Otto-Hess scholarship for Luisa Gündel
The German society of cardiology (DGK) awarded Luisa Gündel the Otto-Hess scholarship for the execution of her MD thesis. The Otto-Hess scholarship supports excellent MD research projects.
Poster prize at PharmTox Summit
Paula Vaccarello won the poster prize at the 2021 Annual Meeting of the German Society of Pharmacology and Toxicology for her Poster on "MicroRNA-21 as a potential therapeutic target in Idiopathic Pulmonary Fibrosis".
A macrophage small RNA promotes cardiac fibrosis
Deepak Ramanujam and Anna Patricia Schön from the IPT have hitherto discovered a previously unknown molecular function of microRNA-21 (miR-21) that promotes fibrosis through its action in macrophages. This study suggests that macrophages hold promise as target cells for RNA-based therapy against miR-21. These findings have recently been published in the #1 Cardiovascular Journal Circulation(link is external).
Inhalation spray agains pulmonary fibrosis after COVID-19
Patients who have had Covid-19 often suffer from reduced lung function for a long time afterwards. One cause of this is scarring of the lung tissue, known as pulmonary fibrosis. A small endogenous RNA molecule, microRNA, is suspected of driving this disease process. Synthetically produced inhibitors (anti-miR oligonucleotides) that neutralize microRNA would be a promising therapeutic strategy. However, when administered intravenously, the drug often does not reach the cells of the organ in question. In the case of the lung, the affected cells can be reached directly by inhalation.
The aim of the "Anti-miR against Pulmonary Fibrosis" project, headed by Stefan Engelhardt, Professor of Pharmacology and Toxicology at TUM, is to develop an inhalation method with the project partner Isar Bioscience GmbH, with which locally high drug concentrations can be achieved in the lungs. This should prevent the development of pulmonary fibrosis as a consequence of covid-19 disease.
Next step towards RNA-based therapy of heart failure:
In a collaborative effort, Rabea Hinkel (MRI TUM) and Deepak Ramanujan from the IPT successfully demonstrated the efficacy of synthetic inhibitors of microRNA miR-21 in a pig model for myocardial ischemia. Recapitulating the situation in human patients where, after myocardial infarction, dysregulation of microRNAs contributes to pathologic cardiac hypertrophy and fibrosis, they showed that inhibition of miR-21 significantly ameliorates the phenotype. Their publication in JACC, entitled „AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury“, was selected as the Paper of the Month by the German center for Cardiovascular Research (DZHK).
Poster prize at PharmTox Summit
Christina Beck won a poster prize at the 2020 Annual Meeting of the German Society of Pharmacology and Toxicology for her Poster on "Inhibition of miR-21 mediates cardioprotection by preferential target regulation in non-myocytes".
Otto-Hess poster prize
Congratulations to Anna Patricia Schön for receiving the 1st place of the Otto-Hess poster prize 2019 and to Christina Beck for winning the 1st place Hans-Jürgen-Bretschneider poster prize 2019 awarded by the Deutsche Gesellschaft für Kardiologie.
The German Research Foundation funds research into molecular regulation in the cardiovascular system
The German Research foundation has approved funding for a new collaborative research center ("Sonderforschungsbereich", short "SFB") at the behest of the Technical University of Munich (TUM), Goethe University Frankfurt and other partners. Over the next four years, the 30-partner consortium will investigate the role of non-coding RNAs in the cardiovascular system and will receive funding around 11 million euros of this purpose.
Otto-Hess scholarship for Paula Uibel
MD student Paula Uibel has been awarded the Otto-Hess scholarship for 2019. The Otto-Hess scholarship awarded by the Deutsche Gesellschaft für Herz- und Kreislaufforschung (DKG) supports excellent MD research projects
Christina Beck won one out of three poster prizes at the 2019 Annual Meeting of the German Society of Pharmacology and Toxicology for her Poster on "Argonaute immunoprecipitation and RNA sequencing to identify the targets of microRNAs-21 and -29 in the mammalian heart"
Chair of Pharmacology and Toxicology at Salzburg University for Antonio Sarikas
Antonio Sarikas, group leader at the IPT since 2009 has accepted an offer by the Medical University of Salzburg (Austria) as Chair of Pharmacology and Toxicology. He starts January 2019 and we are actively looking for a successor.
DGK Stipend for Karin Ziegler
Karin Ziegler has been awarded the 2018 DGK stipend for her project on "Characerization of the symathetic control of cardiac immune cells".
Congratulation to Anna Patricia Schön for receiving the Segnitz-Ackermann prize awarded by the Deutsche Stiftung für Herzforschung!
The award ceremony was at the DGK Basic science meeting in October 2018 in Berlin.
Quelle: "DGK/Stefan Erhard"
Otto-Hess poster prize
Congrats to Karin Ziegler on winning the first place of the Otto-Hess-Poster prize! She received the award for the best poster presentation in the Otto-Hess-Poster session at the 83th annual meeting of the German Cardiac Society in Mannheim.
Quelle: "DGK/Thomas Hauss"